In Vitro Cytotoxicity and Transforming Potential of Industrial Carbon Dust (Fibers and Particles) in Syrian Hamster Embryo (SHE) Cells

Autor: Jeanine Fournier, C. Coulais, F. Terzetti, Yves Guichard, Christian Darne, Stéphane Binet, Laurent Gaté
Přispěvatelé: Département Polluants et Santé, Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Laboratoire de Réactivité de Surface (LRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2010
Předmět:
epithelial-cells
010501 environmental sciences
medicine.disease_cause
01 natural sciences
nanotubes
chemistry.chemical_compound
Cricetinae
Chrysotile
Aluminum Oxide
Graphite
Cytotoxicity
nanomaterials
Cells
Cultured
Mineral Fibers
Air Pollutants
0303 health sciences
she cell transformation
Cytotoxins
fullerene
Polyacrylonitrile
Dust
General Medicine
Cell Transformation
Neoplastic
silica
cytotoxicity
contact-dermatitis
Environmental Monitoring
Asbestos
Serpentine
Silicon dioxide
Hamster
Nanotechnology
Air Pollutants
Occupational
In Vitro Techniques
Biology
Lethal Dose 50
03 medical and health sciences
carbon fibers
medicine
Animals
Particle Size
Carcinogen
Cell Proliferation
030304 developmental biology
0105 earth and related environmental sciences
Dose-Response Relationship
Drug
Mesocricetus
genotoxicity
Electron Spin Resonance Spectroscopy
Public Health
Environmental and Occupational Health
toxicity
[CHIM.CATA]Chemical Sciences/Catalysis
Embryo
Mammalian
peroxidation
Carbon
chemistry
surface reactivity
carbon particles
Aviation
Reactive Oxygen Species
Genotoxicity
Nuclear chemistry
Zdroj: Annals of Occupational Hygiene
Annals of Occupational Hygiene, Oxford University Press (OUP), 2010, 54 (5), pp.532-544. ⟨10.1093/annhyg/meq012⟩
Annals of Occupational Hygiene, 2010, 54 (5), pp.532-544. ⟨10.1093/annhyg/meq012⟩
ISSN: 1475-3162
0003-4878
Popis: Times Cited: 1 Article English Cited References Count: 31 632ie; Carbon fibers have many applications, mainly in high-tech industries such as the aviation industry. Eleven carbon samples (fibers and particles) coming from an aeronautic group were tested for their cytotoxicity and carcinogenic potential using in vitro short-term assays in Syrian hamster embryo cells. These samples were taken during each important step of the process, i.e. from the initial heating of polyacrylonitrile fibers to pure carbon fibers. They were compared to an asbestos fiber, an amorphous silica, and two commercial graphite powders. Their physical chemical characteristics and their capacity to release reactive oxygen species (ROS) were determined. This study showed that none of the carbon samples was able to generate ROS as measured by Electron Paramagnetic Resonance analysis, and in our biological assays, they demonstrated no morphological transformation potential and low cytotoxicity compared to positive control (chrysotile asbestos).
Databáze: OpenAIRE
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