Use of Antidiabetic Drugs in the U.S., 2003–2012
| Autor: | David Moeny, Vicky Borders-Hemphill, Diane K. Wysowski, Christian Hampp |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Drug Research design medicine.medical_specialty Prescription Drugs Endocrinology Diabetes and Metabolism media_common.quotation_subject Pharmacy Drug Prescriptions Rosiglitazone Pharmacotherapy Glucagon-Like Peptide 1 Internal Medicine medicine Humans Hypoglycemic Agents Medical prescription Intensive care medicine media_common Marketing of Health Services Pharmacies Advanced and Specialized Nursing Dipeptidyl-Peptidase IV Inhibitors business.industry Sitagliptin Phosphate Triazoles Metformin United States Sulfonylurea Compounds Diabetes Mellitus Type 2 Pyrazines Sitagliptin Drug Therapy Combination Thiazolidinediones business medicine.drug |
| Zdroj: | Diabetes Care. 37:1367-1374 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc13-2289 |
| Popis: | OBJECTIVE To describe market trends for antidiabetic drugs, focusing on newly approved drugs, concomitant use of antidiabetic drugs, and effects of safety concerns and access restrictions on thiazolidinedione use. RESEARCH DESIGN AND METHODS Nationally projected data on antidiabetic prescriptions for adults dispensed from U.S. retail pharmacies were extracted from IMS Health Vector One National and Total Patient Tracker for 2003–2012 and from Encuity Research Treatment Answers and Symphony Health Solutions PHAST Prescription Monthly for 2012. RESULTS Since 2003, the number of adult antidiabetic drug users increased by 42.9% to 18.8 million in 2012. Metformin use increased by 97.0% to 60.4 million prescriptions dispensed in retail pharmacies in 2012. Among antidiabetic drugs newly approved for marketing between 2003 and 2012, the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin had the largest share with 10.5 million prescriptions in 2012. Rosiglitazone use plummeted to CONCLUSIONS The antidiabetic drug market is characterized by steady increases in volume, and newly approved drugs experienced substantial uptake, especially DPP-4 inhibitors. The use of rosiglitazone has been negligible since restrictions were put in place in 2011. Further study is needed to understand why one-third to one-half of other noninsulin antidiabetic drug use was not concomitant with metformin use despite guidelines recommending that metformin be continued when other agents are added to treatment. |
| Databáze: | OpenAIRE |
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