Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury
| Autor: | Grégoire Courtine, Isabel Vollenweider, Aya Takeoka, Silvia Arber |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
sensory feedback
Spinal Cord Regeneration proprioception Muscle spindle Sensory system Hindlimb Biology descending detour circuit formation General Biochemistry Genetics and Molecular Biology Lesion 03 medical and health sciences Mice 0302 clinical medicine medicine Biological neural network Animals Spinal cord injury Early Growth Response Protein 3 Muscle Spindles Spinal Cord Injuries 030304 developmental biology Feedback Physiological Neurons 0303 health sciences Biochemistry Genetics and Molecular Biology(all) Anatomy Spinal cord medicine.disease medicine.anatomical_structure medicine.symptom Neuroscience 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Cell |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2014.11.019 |
| Popis: | SummarySpinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional muscle spindle feedback to determine the role of this sensory channel in gait control and locomotor recovery after spinal cord injury. High-resolution kinematic analysis of intact mutant mice revealed proficient execution in basic locomotor tasks but poor performance in a precision task. After injury, wild-type mice spontaneously recovered basic locomotor function, whereas mice with deficient muscle spindle feedback failed to regain control over the hindlimb on the lesioned side. Virus-mediated tracing demonstrated that mutant mice exhibit defective rearrangements of descending circuits projecting to deprived spinal segments during recovery. Our findings reveal an essential role for muscle spindle feedback in directing basic locomotor recovery and facilitating circuit reorganization after spinal cord injury. |
| Databáze: | OpenAIRE |
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