Therapy and Prophylaxis of Peritoneal Metastases from Colorectal Cancer
| Autor: | Jiří Tomášek, Libor Němec, Roman Šefr |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Peritoneal surface Colorectal cancer business.industry Systemic chemotherapy Disease Cytoreduction Surgical Procedures Hyperthermia Induced medicine.disease Gastroenterology Combined Modality Therapy Peritoneal carcinomatosis Clinical trial Oncology Internal medicine medicine Humans Hyperthermic intraperitoneal chemotherapy business Cytoreductive surgery Colorectal Neoplasms Peritoneal Neoplasms |
| Zdroj: | Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. 32(5) |
| ISSN: | 1802-5307 |
| Popis: | Stage IV colorectal cancer is associated with high mortality, and the prognosis is significantly worse for patients have peritoneal metastases. Peritoneal carcinomatosis from colorectal cancer was considered incurable with an infaust prognosis. Median survival of untreated patients is about 6 months and palliative systemic chemotherapy can prolonge this time up to 20 months. Patients with this disease were previously only surgically treated if they had severe clinical symptoms or complications. This view has changed dramatically over the past 15 years. Aggressive cytoreductive surgery in combination with intraperitoneal chemotherapy may prolong median survival for more than 40 months in selected patients. The Peritoneal Surface Oncology Group International (PSOGI), the international authority on the treatment of peritoneal tumors, recommends cytoreduction with intraperitoneal chemotherapy as the standard of care for selected patients with moderate-to-small volume peritoneal metastases secondary to colorectal cancer. Macroscopic cytoreduction appears to be essential; however, the role of hyperthermic intraperitoneal chemotherapy and the optimal chemotherapeutic agent for intraperitoneal lavage to treat peritoneal metastases from colorectal cancer remain unclear. The results of ongoing and future clinical trials are eagerly awaited. |
| Databáze: | OpenAIRE |
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