HPLC methods for quantifying anticancer drugs in human samples: A systematic review
| Autor: | Reyhaneh Sabourian, Mannan Hajimahmoodi, Seyedeh Zohreh Mirjalili, Maliheh Safavi, Fateme Chavoshy, Negar Namini |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Drug medicine.medical_specialty media_common.quotation_subject Metabolite Liquid-Liquid Extraction Biophysics Cancer therapy MEDLINE Antineoplastic Agents 01 natural sciences Biochemistry Mass Spectrometry 03 medical and health sciences chemistry.chemical_compound Pharmacokinetics Internal medicine Neoplasms medicine Humans In patient Dosing Molecular Biology Chromatography High Pressure Liquid 030304 developmental biology media_common 0303 health sciences business.industry 010401 analytical chemistry Solid Phase Extraction Cell Biology 0104 chemical sciences chemistry Spectrophotometry Ultraviolet business Dose selection |
| Zdroj: | Analytical biochemistry. 610 |
| ISSN: | 1096-0309 |
| Popis: | Pharmacokinetic (PK) study of anticancer drugs in cancer patients is highly crucial for dose selection and dosing intervals in clinical applications. Once an anticancer drug is administered, it undergoes various metabolic pathways; to determine these pathways, it is necessary to follow the administered drug in biological samples via different analytical methods. In addition, multi-drug quantification methods in patients undergoing multi-drug regimens of cancer therapy can have several benefits, such as reduced sampling time and analysis costs. In order to collect and categorize these studies, we conducted a systematic review of HPLC methods reported for the analysis of anticancer drugs in biological samples. A systematic search was performed on PubMed Medline, Scopus, and Web of Science databases, and 116 studies were included. In summary of included studies, when the objective of a method was to quantify a single drug, MS, or UV detectors were utilized equivalently. On the other hand, in methods with the aim of quantifying drug and metabolite(s) in a single run, MS detectors were the most utilized. This review can provide a comprehensive insight for researchers prior to developing a quantification method and selecting a detector. |
| Databáze: | OpenAIRE |
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