Radioiodine in the treatment of medullary carcinoma of the thyroid
| Autor: | Sydney E. Salmon, Dennis D. Patton, Dorothea E. Hellman, Mark Kartchner, Robert E. O'Mara, James D. Van Antwerp |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Calcitonin
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Iodine Biochemistry Follicular cell Iodine Radioisotopes Endocrinology Internal medicine medicine Carcinoma Humans Thyroid Neoplasms business.industry Biochemistry (medical) Thyroid Thyroidectomy medicine.disease Pentagastrin medicine.anatomical_structure Medullary carcinoma chemistry Female business medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 48(3) |
| ISSN: | 0021-972X |
| Popis: | Medullary carcinoma (MC) of the thyroid, in contrast to papillary-follicular carcinoma, fails to concentrate iodine and thus has not been treated with radioactive iodine. We have successfully treated a 16-yr-old Mexican-American girl with residual MC after maximal thyroidectomy (Tx), utilizing radioiodine (131I) to deliver radiation to residual follicular cells in the tumor bed. Immediately after Tx, plasma thyrocalcitonin levels before and during calcium infusion were all elevated (640--1200 pg/ml). 131I (150 mCi) was administered 12 days after Tx after four daily im injections of bovine TSH. Three months after 131I therapy, thyrocalcitonin levels before and during calcium infusion were all normal (less than 50 pg/ml). Ten months after 131I therapy, thyrocalcitonin levels before and after iv pentagastrin were all normal (less than 60 pg/ml). These results suggest that parafollicular cells are radiosensitive, and that therapeutic levels of radiation can be delivered to these cells after Tx if iodine trapping by the remaining follicular cells is enhanced by high levels of circulating TSH. 131I may be the therapy of choice for MC after Tx, if disease has not spread beyond the area proximate to the thyroid gland. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|