Aspiration-induced Lung Injury: Experimental and Human Studies

Autor:	M. A. Matthay, Z. A. Matthay, G. Mednick
Rok vydání:	2006
Předmět:	medicine.medical_specialty ARDS business.industry respiratory system Lung injury medicine.disease Drug overdose Gastroenterology respiratory tract diseases Sepsis Clinical trial Pneumonia Internal medicine medicine Etiology medicine.symptom business Altered level of consciousness
Zdroj:	Yearbook of Intensive Care and Emergency Medicine ISBN: 9783540301554 Intensive Care Medicine ISBN: 9780387301563
DOI:	10.1007/3-540-33396-7_33
Popis:	Aspiration of gastric and oropharyngeal contents is an important clinical cause of acute lung injury (ALI) that has been recognized for more than 50 years. Epidemiologic studies of ALI, as well as clinical trials, have identified aspiration-induced lung injury as one of the major causes of ALI and the acute respiratory distress syndrome (ARDS) [1], [2]. The most important etiological factor for aspiration-related lung injury is a depressed level of consciousness [3]. One group of investigators found that an altered level of consciousness was the major predisposing factor in 68% of cases [4]. Like other clinical disorders that predispose patients to the development of ALI, aspiration of gastric contents may be associated with other clinical risk factors including primary pneumonia, sepsis, hypotension, and drug overdose [2].
Databáze:	OpenAIRE
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