Towards Controlling the Reactivity of Enzymes in Mechanochemistry: Inert Surfaces Protect β‐Glucosidase Activity During Ball Milling
| Autor: | Karine Auclair, Tomislav Friščić, Shaghayegh Ostadjoo, Fabien Hammerer |
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| Rok vydání: | 2019 |
| Předmět: |
Green chemistry
Polymers Surface Properties General Chemical Engineering 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis chemistry.chemical_compound Mechanochemistry Cellulases Environmental Chemistry Organic chemistry General Materials Science Reactivity (chemistry) Cellulose Ball mill Mechanical Phenomena Inert Aqueous solution 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent Kinetics General Energy chemistry 0210 nano-technology |
| Zdroj: | ChemSusChem. 13:106-110 |
| ISSN: | 1864-564X 1864-5631 |
| DOI: | 10.1002/cssc.201902752 |
| Popis: | The activity of β-glucosidases-the enzymes responsible for the final step in the enzymatic conversion of cellulose to glucose-can be maintained and manipulated under mechanochemical conditions in the absence of bulk solvent, either through an unexpected stabilization effect of inert surfaces, or by altering the enzymatic equilibrium. The reported results illustrate unique aspects of mechanoenzymatic reactions that are not observable in conventional aqueous solutions. They also represent the first reported strategies to enhance activity and favor either direction of the reaction under mechanochemical conditions. |
| Databáze: | OpenAIRE |
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