Adverse Reactions to Cephalothin and Cephapirin
| Autor: | James G. Taggart, W. Eugene Sanders, Joseph E. Johnson |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male Cefalotin Time Factors Pyridines medicine.drug_class medicine.medical_treatment Cephalosporin Antibiotics Blood Sedimentation Sulfides Pharmacology Drug Hypersensitivity Pharmacokinetics Cephalothin Acetamides medicine Humans Adverse effect Saline Skin Tests Dose-Response Relationship Drug business.industry Penicillin G Hemagglutination Tests General Medicine medicine.disease Blood Cell Count Cephalosporins Anesthesia Injections Intravenous Serum sickness Drug Evaluation business Cephapirin medicine.drug |
| Zdroj: | New England Journal of Medicine. 290:424-429 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | The pharmacokinetics and tolerance of cephalothin and cephapirin (a semisynthetic cephalosporin), were evaluated in 40 healthy subjects. Each of the drugs was administered to 15 subjects in increasing doses up to 2.0 g by rapid intravenous infusion four times daily. Equivalent volumes of saline solution were given to 10 control subjects. An illness resembling serum sickness developed in all 30 drug-treated subjects within two to four weeks, whereas the control subjects remained well. The illnesses seemed to result from hypersensitivity to the drugs or their degradation products and not from other chemical or infectious agents. The extraordinarily high rate of reactions was apparently due to the rate of drug infusion or the high doses employed or both. Physicians should be alert to the possibility of similar reactions among hospitalized patients who are receiving large doses of cephalosporins by the intravenous route. (N Engl J Med 290:424–429, 1974) |
| Databáze: | OpenAIRE |
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