Timentin (ticarcillin and clavulanic acid) in combination with aminoglycosides in the treatment of febrile episodes in neutropenic children
| Autor: | J. B. Leauté, G. Schaison, G. Leverger, Ph. Reinert |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Neutropenia Adolescent Fever Penicillins Clinical success Clavulanic Acids Neoplasms Internal medicine Clavulanic acid medicine Humans Ticarcillin Effective treatment Pharmacology (medical) Ticarcillin/clavulanic acid Child Pharmacology Leukemia business.industry Aminoglycoside Infant Bacterial Infections medicine.disease Anti-Bacterial Agents Drug Combinations Aminoglycosides Infectious Diseases Child Preschool Drug Evaluation Drug Therapy Combination Female Netilmicin business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 17:177-181 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/17.suppl_c.177 |
| Popis: | Timentin (ticarcillin + clavulanic acid) combined with an aminoglycoside usually netilmicin, was given to 33 children with neutropenic haematological malignancies. The combination of Timentin and aminoglycoside was effective treatment in 27 (87%) of 31 febrile episodes. There were four failures and three results which could not be interpreted. Bacteriological investigations were positive in 13 patients, three strains were resistant to ticarcillin but all were sensitive to Timentin. Clinical success, based upon reduction of fever within 48 h of treatment, was identical whether an organism was isolated or not. The combination of Timentin plus aminoglycoside was very successful and represents one of the best combinations available for empirical treatment for febrile neutropenic children. |
| Databáze: | OpenAIRE |
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