| Autor: |
Alyssa Shapiro, Jessica Anderson, Prince Mtenthaonga, Watson Kumwenda, Meaghan Bond, Richard Schwarz, Jennifer Carns, Ryan Johnston, Queen Dube, Msandeni Chiume, Rebecca Richards-Kortum |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Pediatrics. 150(2) |
| ISSN: |
1098-4275 |
| Popis: |
OBJECTIVESBiliSpec is a low-cost spectrophotometric reader and disposable paper-based strip to quantify total serum bilirubin from several blood drops. This study was a prospective evaluation of BiliSpec in 2 neonatal wards in Malawi compared with a reference standard bilirubinometer over a large range of bilirubin and hematocrit levels.METHODSThe accuracy of BiliSpec and a transcutaneous bilirubinometer were compared with the reference standard of spectrophotometry for 475 blood samples collected from 375 subjects across a range of total serum bilirubin concentrations from 0.0 to 33.7 mg/dL. The development of error grids to assess the clinical effects of measurement differences is reported.RESULTSBiliSpec was found to have a mean bias of −0.48 mg/dL and 95% limits of agreement of −5.09 mg/dL to +4.12 mg/dL. Results show 90.7% of BiliSpec measurements would have resulted in the same clinical decision as the reference standard, whereas 55.0% of transcutaneous bilirubin measurements would have resulted in the same clinical decision as the reference standard.CONCLUSIONSThis evaluation supports use of BiliSpec to provide accurate, low-cost, point-of-care bilirubin measurements in low-resource hospitals. Future work is needed to evaluate BiliSpec among a larger number of users. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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