Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes
| Autor: | Ronan Roussel, Laurent Larifla, Sonia BenAbdallah, Suriya Maimaitiming, Séverine Ferdinand, Anne Blanchet-Deverly, J.-P. Donnet, Fritz-Line Vélayoudom-Céphise, Lydia Foucan, A. Atallah |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Genotype West Indies Black People Single-nucleotide polymorphism Comorbidity Coronary Artery Disease Type 2 diabetes Polymorphism Single Nucleotide Coronary artery disease Atrial natriuretic peptide Risk Factors Diabetes mellitus Internal medicine Internal Medicine Humans Medicine cardiovascular diseases Myocardial infarction Aged Retrospective Studies business.industry Odds ratio Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Cardiovascular Diseases Cardiology Regression Analysis Female business Atrial Natriuretic Factor Dyslipidemia |
| Zdroj: | American Journal of Hypertension. 25:524-527 |
| ISSN: | 1941-7225 0895-7061 |
| Popis: | Background The atrial natriuretic peptide (ANP) is known mainly for its effects on kidney function and blood pressure homeostasis. We investigated the association between two ANP polymorphisms and pre-existing coronary artery disease (CAD) in patients of African descent with type 2 diabetes (T2D). Methods We conducted a cross-sectional and retrospective study of 218 volunteer Afro-Caribbean patients with T2D. Two polymorphisms (rs5064, 708C>T; and rs5065, 2238T>C) of ANP were genotyped using PCR-restriction fragment length polymorphism analysis. ANCOVA, χ2-test, and logistic regression were used for statistical analysis. Results Among these patients (92 men; 128 women), 67 (30.7%) had CAD, of whom 75% had had myocardial infarction. The frequency of rs5065-C carriers (TC/CC) was significantly lower in patients with CAD than in those without CAD (24 vs. 41%, P = 0.01). The frequency of hypertension did not differ significantly according to genotype. Univariate logistic regression revealed that male sex, age, dyslipidemia, hypertension, and rs5065-C carrier status were associated significantly with CAD. After adjustment for the variables of interest, the odds ratio (ORs) of CAD for rs5065-C carriers (TC/CC) was 0.50 (0.26-0.96; P = 0.038). No association was found between the rs5064 (708C>T) single-nucleotide polymorphisms (SNPs) and pre-existing CAD or cardiovascular risk factors. Conclusions The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent. The relevance of ANP polymorphisms for CAD should be determined in different populations. |
| Databáze: | OpenAIRE |
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