Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1

Autor:	Paul S. Hafen, Andrew S. Law, Catalina Matias, Spencer G. Miller, Jeffrey J. Brault
Rok vydání:	2022
Předmět:	Male Adenine Nucleotides Physiology AMP-Activated Protein Kinases Adenosine Monophosphate AMP Deaminase Mice Inbred C57BL Mice MicroRNAs Inosine Monophosphate Physiology (medical) Animals Muscle Skeletal Muscle Contraction
Zdroj:	Journal of Applied Physiology. 133:1055-1066
ISSN:	1522-1601 8750-7587
Popis:	AMP deaminase 1 (AMPD1) deficiency has been associated with premature muscle fatigue and reduced work capacity, but this finding has been inconsistent. Herein, we report that although AMPD1 knockdown in mouse skeletal muscle does not change maximal isometric force, it negatively impacts muscle function by slowing contraction and relaxation kinetics in EDL muscle but not SOL muscle. Furthermore, AMPD1 knockdown differentially affects the [AMP]/AMPK responses to fatiguing contractions in an intensity-dependent manner in EDL muscle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41579a1a30a3bd8cc7d3152098db6ec https://doi.org/10.1152/japplphysiol.00035.2022 Zobrazit plný text záznamu