SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL FUSED THIAZOLO[3,2A]PYRIMIDINES AS POTENTIAL ANALGESIC AND ANTI-INFLAMMATORY AGENTS
| Autor: | Abd El-Galil E. Amr, Ayman R. Baiuomy, Mohamed A. Al-Omar, Rehab F. Abdel-Rahman, Nagy M. Khalifa |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Analgesics Bicyclic molecule Chemistry medicine.drug_class Analgesic Anti-Inflammatory Agents General Medicine Reference drug Anti-inflammatory Rats Thiazoles Pyrimidines Elemental analysis medicine Organic chemistry Bioorganic chemistry Animals Drug Evaluation Female Rats Wistar Spectral data Biological evaluation |
| Zdroj: | Bioorganicheskaia khimiia. 41(2) |
| ISSN: | 0132-3423 |
| Popis: | Some novel bicyclic thiazolopyrimidine derivatives bearing various substituents have been synthesized through one-pot three-component method. Structures of the target compounds were confirmed by elemental analysis and spectral data. Some selected members of the newly synthesized compounds were investigated for their analgesic and anti-inflammatory activities and revealed pronounced anti-inflammatory activity greater than that of indomethacin (reference drug). |
| Databáze: | OpenAIRE |
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