Sex differences in flow cytometry–based platelet reactivity in stable outpatients suspected of myocardial ischemia
| Autor: | Diederick E. Grobbee, Leo Timmers, Dominique P.V. de Kleijn, Ingrid E.M. Bank, A. Mosterd, Mirthe Dekker, Gert J. de Borst, Rolf T. Urbanus, Suzanne J.A. Korporaal, Farahnaz Waissi, Asbjørn M. Scholtens, Gerard Pasterkamp |
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| Přispěvatelé: | Graduate School, ACS - Heart failure & arrhythmias |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
platelet
sex differences Aspirin medicine.medical_specialty lcsh:RC633-647.5 flow cytometry Renal function Fibrinogen binding Hematology lcsh:Diseases of the blood and blood-forming organs Gastroenterology antiplatelet therapy P2Y12 Platelet degranulation Internal medicine medicine platelet activation Platelet Original Article Platelet activation Original Articles: Thrombosis medicine.drug Whole blood |
| Zdroj: | Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 879-885 (2020) Research and Practice in Thrombosis and Haemostasis Research and practice in thrombosis and haemostasis, 4(5), 879-885. Wiley-Blackwell Publishing Ltd |
| ISSN: | 2475-0379 |
| Popis: | Background Antiplatelet therapy is the mainstay of secondary prevention of cardiovascular events. Studies suggest that women do not obtain equal therapeutic benefit from antiplatelet therapy compared with men. The link between sex differences in platelet biology and response to antiplatelet therapies is unclear. We therefore investigated the role of sex differences in platelet reactivity in a cohort of outpatients with chest pain, in response to treatment with antiplatelet agents. Methods Platelet reactivity was measured in 382 randomly selected patients participating in the Myocardial Ischemia Detection by Circulating Biomarkers (MYOMARKER) study, an observational cohort study of outpatients suspected of myocardial ischemia. In all patients, blood was collected during diagnostic workup, and platelet reactivity was assessed with a flow cytometry–based platelet activation test that quantifies both platelet degranulation (P‐selectin expression) and platelet aggregation (fibrinogen binding to integrin αIIbβ3) in whole blood. Results Platelet reactivity was higher in women compared with men when activated with protease activating receptor 1–activating peptide SFLLRN (PAR1‐AP) and adenosine 5′‐phosphate (ADP), independent of age, basal activation status, estimated glomerular filtration rate |
| Databáze: | OpenAIRE |
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