Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020
| Autor: | Wycliffe E. Wei, Calvin J Chiew, Sarah E. Yong, Matthias Paul Han Sim Toh, Vernon J. Lee, Zongbin Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Health (social science) Coronavirus disease 2019 (COVID-19) Epidemiology Health Toxicology and Mutagenesis Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus 03 medical and health sciences 0302 clinical medicine Health Information Management 030225 pediatrics Pandemic Cluster Analysis Humans Medicine 030212 general & internal medicine Symptom onset Asymptomatic Diseases Singapore Outbreak Report SARS-CoV-2 business.industry Transmission (medicine) General Medicine Middle Aged Disease control Female Contact Tracing Coronavirus Infections business Contact tracing |
| Zdroj: | Morbidity and Mortality Weekly Report |
| ISSN: | 1545-861X 0149-2195 |
| DOI: | 10.15585/mmwr.mm6914e1 |
| Popis: | Presymptomatic transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), might pose challenges for disease control. The first case of COVID-19 in Singapore was detected on January 23, 2020, and by March 16, a total of 243 cases had been confirmed, including 157 locally acquired cases. Clinical and epidemiologic findings of all COVID-19 cases in Singapore through March 16 were reviewed to determine whether presymptomatic transmission might have occurred. Presymptomatic transmission was defined as the transmission of SARS-CoV-2 from an infected person (source patient) to a secondary patient before the source patient developed symptoms, as ascertained by exposure and symptom onset dates, with no evidence that the secondary patient had been exposed to anyone else with COVID-19. Seven COVID-19 epidemiologic clusters in which presymptomatic transmission likely occurred were identified, and 10 such cases within these clusters accounted for 6.4% of the 157 locally acquired cases. In the four clusters for which the date of exposure could be determined, presymptomatic transmission occurred 1-3 days before symptom onset in the presymptomatic source patient. To account for the possibility of presymptomatic transmission, officials developing contact tracing protocols should strongly consider including a period before symptom onset. Evidence of presymptomatic transmission of SARS-CoV-2 underscores the critical role social distancing, including avoidance of congregate settings, plays in controlling the COVID-19 pandemic. |
| Databáze: | OpenAIRE |
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