Experimental validation of daily adaptive proton therapy
| Autor: | Michael Matter, Francesca Albertini, Damien C. Weber, Antony J. Lomax, Lena Nenoff, Klara Uher, Serge Krier, Marjolaine Charmillot |
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| Rok vydání: | 2021 |
| Předmět: |
Online adaption
End to end test Computer science Logfile Monte Carlo method 610 Medicine & health Workflow implementation 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Software Treatment plan Radiology Nuclear Medicine and imaging Proton therapy Adaptive therapy Antropomorphic phantom Simulation Radiological and Ultrasound Technology Phantoms Imaging business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Experimental validation Workflow 030220 oncology & carcinogenesis Anthropomorphic phantom Radiotherapy Intensity-Modulated business Platelet Aggregation Inhibitors |
| Zdroj: | Nenoff, Lena; Matter, Michael; Charmillot, Marjolaine; Krier, Serge; Uher, Klara; Weber, Damien Charles; Lomax, Antony John; Albertini, Francesca (2021). Experimental validation of daily adaptive proton therapy. Physics in medicine and biology, 66(20) Institute of Physics Publishing IOP 10.1088/1361-6560/ac2b84 Physics in Medicine and Biology, 66 (20) |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/1361-6560/ac2b84 |
| Popis: | Anatomical changes during proton therapy require rapid treatment plan adaption to mitigate the associated dosimetric impact. This in turn requires a highly efficient workflow that minimizes the time between imaging and delivery. At the Paul Scherrer Institute, we have developed an online adaptive workflow, which is specifically designed for treatments in the skull-base/cranium, with the focus set on simplicity and minimizing changes to the conventional workflow. The dosimetric and timing performance of this daily adaptive proton therapy (DAPT) workflow has been experimentally investigated using an in-house developed DAPT software and specifically developed anthropomorphic phantom. After a standard treatment preparation, which includes the generation of a template plan, the treatment can then be adapted each day, based on daily imaging acquired on an in-room CT. The template structures are then rigidly propagated to this CT and the daily plan is fully re-optimized using the same field arrangement, DVH constraints and optimization settings of the template plan. After a dedicated plan QA, the daily plan is delivered. To minimize the time between imaging and delivery, clinically integrated software for efficient execution of all online adaption steps, as well as tools for comprehensive and automated QA checks, have been developed. Film measurements of an end-to-end validation of a multi-fraction DAPT treatment showed high agreement to the calculated doses. Gamma pass rates with a 3%/3 mm criteria were >92% when comparing the measured dose to the template plan. Additionally, a gamma pass rate >99% was found comparing measurements to the Monte Carlo dose of the daily plans reconstructed from the logfile, accumulated over the delivered fractions. With this, we experimentally demonstrate that the described adaptive workflow can be delivered accurately in a timescale similar to a standard delivery. Physics in Medicine and Biology, 66 (20) ISSN:1361-6560 ISSN:0031-9155 |
| Databáze: | OpenAIRE |
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