Methodologies and Emerging Technologies for the Evaluation of the Hematopoietic System

Autor:	Florence Poitout-Belissent, Allison Vitsky, Mark A. Smith, Madhu P. Sirivelu
Rok vydání:	2022
Předmět:	Artificial Intelligence Bone Marrow Hematopoietic System Bone Marrow Cells Cell Biology Toxicology Molecular Biology Hematopoiesis Pathology and Forensic Medicine
Zdroj:	Toxicologic Pathology. 50:867-870
ISSN:	1533-1601 0192-6233
DOI:	10.1177/01926233221128755
Popis:	Hematology and bone marrow analysis is central to our understanding of the hematopoietic system and how it responds to insults, and this session presented during the 2022 STP symposium provided a review of current and novel approaches for the evaluation of the hematopoietic system in the context of nonclinical investigations. This publication summarizes the information presented on novel approaches for evaluation of the hematopoietic system using automated hematology analyzers, including details around the quantitative assessment of bone marrow cell suspensions as well as introducing several newly available hematology parameters. It was followed by a discussion on intravital microscopy and live cell imaging and how these methods can assist with de-risking hematopoiesis-associated safety concerns, and a review of recent assays using artificial intelligence for the evaluation of bone marrow.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38a5c982a9c30ac7fd84045c6163af0 https://doi.org/10.1177/01926233221128755 Zobrazit plný text záznamu