Spleen-targeted 114In(m) via normal and heat-damaged red cells in the mouse: isotope distribution and bone marrow damage
| Autor: | Jackson Nc, Jackson H |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Erythrocytes Hot Temperature Chemistry Ratón Indium Radioisotopes Spleen General Medicine Hematopoietic Stem Cells Molecular biology Red blood cell Mice medicine.anatomical_structure Pharmacokinetics Liver Toxicity Immunology medicine Animals Radiology Nuclear Medicine and imaging Tissue Distribution Bone marrow Progenitor cell Quantitative analysis (chemistry) |
| Zdroj: | Nuclear medicine communications. 21(9) |
| ISSN: | 0143-3636 |
| Popis: | 114In m -labelled heat-damaged erythrocytes (HDRBC) in BDF 1 mice were quantitatively much less successful in spleen targeting than in the rat. Unheated labelled cells (NRBC) were an even less effective vector. Radiobiological effects manifest in the spleen (weight loss) and white cell count were nevertheless substantial, comparable in both groups and unchanged after 14 days. Considerable early renal loss of indium is inferred in the NRBC animals, but in the HDRBC group a high proportion was retained in the liver. Progenitor cell marrow cultures indicated acute transitory lethal effects with only partial recovery at termination; the marrow concentration of indium was the same in both groups. |
| Databáze: | OpenAIRE |
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