| Autor: |
Kessel, Sebastiaan P. Van, Jong, Hiltje R. De, Winkel, Simon L., Leeuwen, Sander S. Van, Nelemans, Sieger A., Permentier, Hjalmar, Keshavarzian, Ali, Aidy, Sahar El |
| Rok vydání: |
2020 |
| DOI: |
10.6084/m9.figshare.13115487.v1 |
| Popis: |
Additional file 1: Supplementary Results – Metagenomic analysis of deaminating bacteria and E. lenta in PD and HC fecal and mucosal samples. Fig. S1 – NMR and MS confirmation of levodopa product, 3-(3,4-dihydroxyphenyl)propionic acid. Fig. S2 – 5-HTP conversion by Clostridium sporogenes. Fig. S3 – Growth curves of CSΩfldC and CSΩCLOSPO_01732, and 5-HT production. Fig. S4 – Initial effect of DHPPA on natural ileal contractility and no effect of levodopa on acetylcholine induced twitch. Fig. S5 – Phylogenetic tree of C. sporogenes FldH and EDU38870. Fig. S6 – Fecal-incubations from healthy age-matched controls. Fig. S7 – 3-HPPA is produced by E. lenta. Fig. S8 – Analysis of 16s rDNA metagenomics data of deaminating bacteria and E. lenta in PD and HC fecal and mucosal samples. Table S1 – Values and statistical results corresponding to Fig. 2B. Table S2 – MS confirms that DHPPA is extracted from PD and HC samples using alumina extraction method. Table S3 – Plasmids and primers used in this study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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