Does the MRI or MRI contrast medium gadopentetate dimeglumine change the oxidant and antioxidant status in humans?
| Autor: | Ebru Gok Oguz, Refik Olmaz, Ahmet Kiykim, Mehmet Horoz, Necati Muşlu, Kenan Turgutalp, Mehmet Ali Sungur, Onur Özhan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Gadolinium DTPA Male Pathology medicine.medical_specialty Antioxidant medicine.medical_treatment media_common.quotation_subject Contrast Media medicine.disease_cause Antioxidants Nephrotoxicity Pathogenesis Liver Function Tests Malondialdehyde Humans Medicine Contrast (vision) Radiology Nuclear Medicine and imaging Prospective Studies media_common Analysis of Variance Radiological and Ultrasound Technology business.industry General Medicine Lipids Magnetic Resonance Imaging Uric Acid Oxidative Stress Contrast medium C-Reactive Protein Case-Control Studies Creatinine Female business Intervertebral Disc Displacement Oxidative stress |
| Zdroj: | Acta Radiologica. 54:30-34 |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1258/ar.2012.120434 |
| Popis: | BackgroundIt has become evident that gadolinium-based contrast agents (GBCA) may have nephrotoxic potential. Oxidative stress is one of the most important pathways in the pathogenesis of iodinated contrast-induced nephropathy.PurposeTo investigate the effects of static magnetic fields and gadopentetate dimeglumine (Magnevist®) on oxidant/antioxidant status via measurement of total antioxidant capacity (TAC), total oxidant status (TOS), and serum malondialdehide (MDA).Material and MethodsTwo age- and sex-matched groups of patients not under oxidative stress conditions that underwent magnetic resonance imaging (MRI) were recruited to this study. While contrast-enhanced (Magnevist®, 0.2 mmol/kg) MRI was performed in group 1, MRI without GBCA was performed in group 2. Fasting blood glucose, C-reactive protein, serum creatinine, liver enzymes, uric acid, and lipid parameters were examined in all patients. Peripheral venous blood samples in order to determine TAC, TOS, and MDA were collected before and 6, 24, and 72 h after the MRI procedures. The TOS:TAC ratio was used as the oxidative stress index (OSI). Patients were followed up to 72 h.ResultsThere were no significant changes in serum TAC, TOS, and MDA levels (Δserum TAC, Δserum TOS, and ΔMDA) in either group 6, 24, or 72 h after the procedures (P > 0.05). Furthermore, OSI did not change after the procedures in either group (P > 0.05).ConclusionMagnetic field and gadopentetate dimeglumine (Magnevist®) do not change the oxidant or antioxidant status at a dose of 0.2 mmol/kg. |
| Databáze: | OpenAIRE |
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