Surveillance Endoscopy in the Management of Hereditary Diffuse Gastric Cancer Syndrome
| Autor: | Devanshi Patel, Gregory Y. Lauwers, Madeline Friedman, Sam S. Yoon, Tomer Adar, Daniel C. Chung, John T. Mullen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Lower risk Gastroenterology 03 medical and health sciences 0302 clinical medicine Gastrectomy Neoplastic Syndromes Hereditary Stomach Neoplasms Internal medicine Signet ring cell carcinoma Gastroscopy medicine Carcinoma Humans Genetic Predisposition to Disease Hepatology business.industry Cancer medicine.disease Surveillance endoscopy 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Lifetime risk Hereditary diffuse gastric cancer business Carcinoma Signet Ring Cell |
| Zdroj: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 19(1) |
| ISSN: | 1542-7714 |
| Popis: | Hereditary diffuse gastric cancer (HDGC) syndrome results from a germline CDH1 mutation, and microscopic foci of signet-ring carcinoma cells (SRCC) are present in nearly all gastrectomy specimens.1 The lifetime risk of invasive gastric cancer (GC) has been thought to be 70%,2 but recent data have suggested a lower risk of 37%.3 Prophylactic total gastrectomy is considered the standard of care, but many patients choose surveillance endoscopy instead. We sought to define the outcomes in CDH1-positive individuals who pursued endoscopic surveillance. |
| Databáze: | OpenAIRE |
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