Tale of two kinases: Protein kinase A and Ca2+/calmodulin-dependent protein kinase II in pre-diabetic cardiomyopathy
| Autor: | Pamela Gaitán-González, Rommel Sánchez-Hernández, José-Antonio Arias-Montaño, Angélica Rueda |
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| Rok vydání: | 2021 |
| Předmět: |
Pre-diabetic cardiomyopathy
medicine.medical_specialty Kinase business.industry Endocrinology Diabetes and Metabolism Cardiomyopathy Minireviews medicine.disease Metabolic syndrome β-Adrenoceptors Pathophysiology Protein kinase A Insulin resistance Endocrinology Internal medicine Diabetes mellitus Diabetic cardiomyopathy Internal Medicine medicine Ca2+/calmodulin-dependent protein kinase II Pre-diabetes business |
| Zdroj: | World Journal of Diabetes |
| ISSN: | 1948-9358 |
| DOI: | 10.4239/wjd.v12.i10.1704 |
| Popis: | Metabolic syndrome is a pre-diabetic state characterized by several biochemical and physiological alterations, including insulin resistance, visceral fat accumulation, and dyslipidemias, which increase the risk for developing cardiovascular disease. Metabolic syndrome is associated with augmented sympathetic tone, which could account for the etiology of pre-diabetic cardiomyopathy. This review summarizes the current knowledge of the pathophysiological consequences of enhanced and sustained β-adrenergic response in pre-diabetes, focusing on cardiac dysfunction reported in diet-induced experimental models of pre-diabetic cardiomyopathy. The research reviewed indicates that both protein kinase A and Ca2+/calmodulin-dependent protein kinase II play important roles in functional responses mediated by β1-adrenoceptors; therefore, alterations in the expression or function of these kinases can be deleterious. This review also outlines recent information on the role of protein kinase A and Ca2+/calmodulin-dependent protein kinase II in abnormal Ca2+ handling by cardiomyocytes from diet-induced models of pre-diabetic cardiomyopathy. |
| Databáze: | OpenAIRE |
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