Cold-Induced Activities of Cytochromes P450 1A1 and 1A2 in Rat Liver: Putative Role of Endogenous Compounds in Induction Mechanism
| Autor: | A. Yu. Grishanova, M. L. Perepechaeva |
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| Rok vydání: | 2013 |
| Předmět: |
Male
animal structures Bilirubin Tocopherols Endogeny General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Mediator Biotransformation Cytochrome P-450 CYP1A2 Corticosterone Cytochrome P-450 CYP1A1 Animals Tocopherol Rats Wistar chemistry.chemical_classification General Medicine Adaptation Physiological Rats Cold Temperature Enzyme Liver chemistry Biochemistry embryonic structures Xenobiotic |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 154:638-641 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-013-2019-2 |
| Popis: | Adaptation to cold includes adaptive changes at the organism and molecular levels. One of the interesting facts is induction of cytochromes P450 subfamily 1A (CYP1A) in the liver of rats, inducible enzymes participating in biotransformation of procarcinogenic xenobiotics, under the effect of moderate cold exposure. Cold activation of CYP1A can be mediated by adaptive changes and the resultant redistribution or intensification of the synthesis of mediator compounds. This hypothesis is verified in the present study. The role of bilirubin, tocopherol, and corticosterone as mediators of cold induction of CYP1A in the rat liver was evaluated. The results indicate that these compounds can be involved in cold induction of CYP1A, but none of them is the only mediator in this process. |
| Databáze: | OpenAIRE |
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