Phenolic acid content and antiadherence activity in the urine of patients treated with cranberry syrup (Vaccinium macrocarpon) vs. trimethoprim for recurrent urinary tract infection
| Autor: | Antonio Muñoz-Hoyos, José Uberos, R. Rodríguez-Belmonte, E. Blanca-Jover, Celia Rodríguez-Pérez, Manuel Molina-Oya, Eduardo Narbona-López |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Hydroxybenzoic acid Urinary system Medicine (miscellaneous) Urine Gastroenterology Microbiology Excretion chemistry.chemical_compound Internal medicine medicine Vaccinium macrocarpon Cranberry TX341-641 E. coli Urinary tract infection Phenolic acid Nutrition and Dietetics Nutrition. Foods and food supply Chemistry Biofilm food and beverages Trimethoprim Proanthocyanidin Surface hydrophobicity Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 18, Iss, Pp 608-616 (2015) |
| ISSN: | 1756-4646 |
| Popis: | The effectiveness of cranberry in the treatment of urinary tract infection (UTI) has been associated with its polyphenol content, particularly proanthocyanidins (PACs) and the inhibition of adherence of Escherichia coli to the uroepithelium. This paper describes a controlled, double blind, clinical trial of children aged over one month with recurrent urinary tract infection. The study aims were to evaluate the safety and efficacy of cranberry syrup in children and to investigate the relationship between the excretion of phenolic acids in urine with the antiadherent activity of cranberry syrup. In the study population, cranberry syrup was found to be similar to trimethoprim, with a rate of UTI (reinfection) of 26% (95% CI 12–41). The administration of cranberry syrup was associated with high levels of hydroxycinnamic and hydroxybenzoic acids in urine; in both cases these molecules present activity in the biofilm inhibition or reduction of surface hydrophobicity of E. coli (Clinical Trials Registry ISRCTN16968287). |
| Databáze: | OpenAIRE |
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