Association between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and hypertension
| Autor: | Daniel Gaudet, Monique Tremblay, Diane Brisson |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Genotype Poly T Physiology Diastole Blood Pressure 030204 cardiovascular system & hematology Overweight Bioinformatics 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Risk Factors Internal medicine Internal Medicine Medicine Humans Genetic Predisposition to Disease Allele Promoter Regions Genetic Alleles Genetic Association Studies Polymorphism Genetic business.industry Middle Aged medicine.disease Obesity 030104 developmental biology Endocrinology Blood pressure Hypertension Female medicine.symptom Cardiology and Cardiovascular Medicine business Somatostatin Body mass index |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 39(6) |
| ISSN: | 1348-4214 |
| Popis: | Despite the numerous common pathways connecting blood pressure regulation to somatostatin (SST) metabolism, the SST gene has never been seen as a significant blood pressure modulator. The aim of this study was to evaluate the association between a poly-T repeat sequence (rs34872250) in the promoter of the SST gene and blood pressure, according to the obesity status. We genotyped 1918 French-Canadian subjects from a founder population. Analyses were performed according to the length of the poly-T repeat sequence on both alleles and divided into two groups, the 13/13-13/14 group and the 13/15-13/16 group. The effect of age, gender, body mass index, antihypertensive drugs and diabetic status were considered. Systolic, diastolic and mean blood pressures are significantly higher among the 13/15-13/16 group in the whole sample (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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