Contrast enhancement in atherosclerosis development in a mouse model : in vivo results at 2 Tesla

Autor: E. Canet Soulas, André Briguet, Linda Chaabane, Philippe Douek, A. Sulaiman, N. Pellet, G. Hadour, F. Thivolet-Béjui, C. Desbleds Mansard, M. C. Bourdillon, Pascal Roy
Přispěvatelé: Laboratoire de Résonance Magnétique Nucléaire (RMN), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Génomique fonctionnelle dans l'athérothrombose (EA 3740), Université Claude Bernard Lyon 1 (UCBL), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL), Hospices Civils de Lyon (HCL)
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Pathology
medicine.medical_specialty
Contrast enhancement
APOLIPOPROTEIN E KNOCKOUT MICE
Arteriosclerosis
Gadolinium
media_common.quotation_subject
[SDV]Life Sciences [q-bio]
Biophysics
chemistry.chemical_element
Contrast Media
MAGNETIC RESONANCE IMAGING
Mice
Transgenic
030204 cardiovascular system & hematology
Sensitivity and Specificity
Severity of Illness Index
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
Magnetics
Mice
0302 clinical medicine
Apolipoproteins E
In vivo
MEDIAL REMODELING
medicine.artery
Image Interpretation
Computer-Assisted
medicine
Organometallic Compounds
Contrast (vision)
Animals
Radiology
Nuclear Medicine and imaging
PERMEABILITY
media_common
Mice
Knockout
Radiological and Ultrasound Technology
medicine.diagnostic_test
Abdominal aorta
Reproducibility of Results
Magnetic resonance imaging
Image Enhancement
Disease Models
Animal
chemistry
ATHEROSCLEROSIS
Permeability (electromagnetism)
medicine.symptom
Zdroj: Magnetic Resonance Materials in Physics, Biology and Medicine
Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Verlag, 2004, 17 (3-6), pp.188-195
ISSN: 0968-5243
1352-8661
Popis: International audience; To develop an MRI method for the evaluation of contrast enhancement in early atherosclerotic plaque development in the abdominal aorta of a mouse model. Male apoE(-/-) mice from three groups, respectively 4 (n = 6), 8 (n = 11) and 16 (n = 4) weeks were included. Axial T I spin echo images of the abdominal aorta were obtained above and below the renal arteries (90 mu m spatial resolution) before and over 1 h after the injection of a macromolecular contrast agent. Signal enhancement was measured in the vessel wall and compared to histological features. Maximal arterial wall signal enhancement was obtained from 16 to 32 min post injection. During this time, the signal-to-noise ratio increased by a factor up to 1.7 in 16 week mice and 2.7 and 2.4 in 8 and 4 weeks mice, respectively. The enhancement of the arterial wall appeared less pronounced in the oldest mice, 16 weeks old, exhibiting more advanced lesions. Using a macromolecular gadolinium agent, contrast uptake in atherogenesis varies with lesion stage and may be related to vessel-wall permeability. Dynamic contrast-enhanced MRI may be useful to evaluate the atherosclerotic plaque activity in mice.
Databáze: OpenAIRE
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