RESVEGA, a Nutraceutical Omega-3/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization

Autor: Ida Chiara Guerrera, Niyazi Acar, Dominique Delmas, Lionel Bretillon, Jean-Paul Pais de Barros, Cerina Chhuon, Virginie Aires, Flavie Courtaut, Céline Olmiere
Přispěvatelé: Université Bourgogne Franche-Comté [COMUE] (UBFC), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Structure Fédérative de Recherche Necker (SFR Necker - UMS 3633 / US24), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoires Théa, Partenaires INRAE, Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Agence Nationale de la Recherche + Association Nationale de la Recherche et de la Technologie (ANRT, 2016/0003) + European Regional Development Fund (ERDF) + Conseil régional de Bourgogne-Franche-Comté., ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du(2011), Julien, Sabine, Laboratoires d'excellence - Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer - - Lipstic2011 - ANR-11-LABX-0021 - LABX - VALID, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer(2011)
Rok vydání: 2021
Předmět:
Proteomics
genetic structures
Angiogenesis
AMD
resveratrol
Pharmacology
Resveratrol
Macular Degeneration
Mice
angiogenesis
chemistry.chemical_compound
0302 clinical medicine
Medicine
Biology (General)
proteomic
Spectroscopy
0303 health sciences
omega-3 fatty acids
General Medicine
3. Good health
Computer Science Applications
Chemistry
medicine.anatomical_structure
Choroidal neovascularization
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Female
medicine.symptom
QH301-705.5
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Nutraceutical
In vivo
Fatty Acids
Omega-3
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
In patient
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
030304 developmental biology
Retina
business.industry
ocular diseases
Organic Chemistry
Macular degeneration
medicine.disease
Choroidal Neovascularization
eye diseases
Disease Models
Animal
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
chemistry
Dietary Supplements
030221 ophthalmology & optometry
sense organs
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 11023, p 11023 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (20), pp.11023. ⟨10.3390/ijms222011023⟩
Volume 22
Issue 20
International Journal of Molecular Sciences, 2021, 22 (20), pp.11023. ⟨10.3390/ijms222011023⟩
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms222011023
Popis: Age-related macular degeneration (AMD) is an eye disease that is characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. At an advanced stage, a blind spot grows in the center of vision, severely handicapping patients with this degenerative condition. Despite therapeutic advances thanks to the use of anti-VEGF, many resistance mechanisms have been found to accentuate the visual deficit. In the present study, we explored whether supplementation with Resvega®, a nutraceutical formulation composed of omega-3 fatty acids and resveratrol, a well-known polyphenol in grapes, was able to counteract laser-induced choroidal neovascularization (CNV) in mice. We highlight that Resvega® significantly reduced CNV in mice compared with supplementations containing omega-3 or resveratrol alone. Moreover, a proteomic approach confirmed that Resvega® could counteract the progression of AMD through a pleiotropic effect targeting key regulators of neoangiogenesis in retina cells in vivo. These events were associated with an accumulation of resveratrol metabolites within the retina. Therefore, a supplementation of omega-3/resveratrol could improve the management or slow the progression of AMD in patients with this condition.
Databáze: OpenAIRE
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