Synthesis and immunomodulatory activity of novel amino acid analogues of fluoxetine

Autor:	Talati, Mamta N., Vemireddy, Sravanthi, Seelam, Siva Deepthi, M., Sampath Kumar Halmuthur.
Rok vydání:	2023
Předmět:	Organic Chemistry
Zdroj:	Synthetic Communications. 53:731-743
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397911.2023.2196024
Popis:	Immunomodulators are assigned as a robust tool for the treatment of various medical conditions like AIDS, cancer and autoimmune diseases. In this work, we have synthesized a series of fluoxetine-based small-molecule immunomodulators. Molecules were synthesized by a convergent strategy, where mitsunobu reaction was conducted to synthesize the common starting material. The novel analogues displayed immunomodulatory potential as indicated by the anti-inflammatory effect derived through the compound’s T cell proliferation inhibitory property. The synthesized novel analogues manifested encouraging biological responses, assure their application as immunomodulators.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31aed53dc6f94c35098996a0f74082a https://doi.org/10.1080/00397911.2023.2196024 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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