Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior
| Autor: | Térèse Laforge, Samuel Deutsch, Sébastien Guillaume, Nader Perroud, Philippe Courtet, Michel Guipponi, Fabrice Jollant, François Le Gal, Patrick Baud, Karine Kohler, Brice Petit, Romano La Harpe, Alain Malafosse, Monique Vessaz |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Acetyltransferases/genetics/metabolism RNA Messenger/genetics/metabolism Prefrontal Cortex Poison control Down-Regulation Single-nucleotide polymorphism Biology Methylation Polymerase Chain Reaction Polymorphism Single Nucleotide Self-Injurious Behavior/genetics Cellular and Molecular Neuroscience ddc:616.89 Young Adult Acetyltransferases Gene expression SNP Humans ddc:576.5 Genetic Predisposition to Disease RNA Messenger Epigenetics Promoter Regions Genetic Genetics (clinical) Genetic association Aged Genetics Aged 80 and over Suicide attempt ddc:614.1 Middle Aged Psychiatry and Mental health Suicide Gene Expression Regulation Female Self-Injurious Behavior Prefrontal Cortex/metabolism |
| Zdroj: | American Journal of Medical Genetics. B, Vol. 150B, No 6 (2009) pp. 799-807 |
| ISSN: | 1552-4841 |
| Popis: | It has recently been proposed that the SSAT gene plays a role in the predisposition to suicidal behavior. SSAT expression was found to be down-regulated in the brain of suicide completers. In addition, a single nucleotide polymorphism (SNP) rs6526342 was associated both with variation in SSAT expression and with suicidal behavior. In this study, we aimed to characterize the relationship between SSAT dysregulation and suicide behavior. To this end, we measured SSAT expression levels in the ventral prefrontal cortex (VPFC) of suicide completers (n = 20) and controls (n = 20) and found them to be significantly down-regulated in suicide victims (P = 0.007). To identify the basis of the regulation of SSAT expression, we performed an association analysis of 309 SNPs with SSAT transcript levels in 53 lymphoblastoid cell lines from the CEPH collection. We then examined the methylation status of the SSAT promoter region in males and females suicide completers and control subjects whose SSAT brain expression had been measured. We found no evidence to support a role for SNPs in controlling the level of SSAT expression. SSAT promoter methylation levels were not different between suicide completers and controls and did not correlate with SSAT expression levels. In addition, we found no indication of a genetic association between suicidal behavior and SNPs located within the SSAT gene. Our study provides new results which show that dysregulation of SSAT expression does play a role in suicide behavior. However, our data do not support any association between rs6526342 and variation in SSAT expression or suicidal behavior. |
| Databáze: | OpenAIRE |
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