Hodgkin's lymphoma, Epstein-Barr virus reactivation and fatal haemophagocytic syndrome
| Autor: | Börje Ridell, S Hasselblom, A Linde |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Pathology medicine.medical_specialty Histiocytosis Non-Langerhans-Cell Lymph node biopsy medicine.disease_cause Herpesviridae Fatal Outcome hemic and lymphatic diseases Internal Medicine medicine Humans Epstein–Barr virus infection Aged medicine.diagnostic_test business.industry Hodgkin's lymphoma medicine.disease Hodgkin Disease Epstein–Barr virus Pancytopenia Lymphoma Histiocytosis Immunology Female Virus Activation business |
| Zdroj: | Journal of Internal Medicine. 255:289-295 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1046/j.0954-6820.2003.01249.x |
| Popis: | Haemophagocytic syndrome is a serious disorder, often related to Epstein-Barr virus (EBV) or other infectious agents. Frequently an underlying immune abnormality or a T-cell lymphoma is present. The combination of haemophagocytosis and Hodgkin's lymphoma seems to be rare. A 70-year-old female with rheumatoid arthritis was admitted with constitutional symptoms, persistent fever, pancytopenia, deranged liver enzymes, lymphadenopathy and splenomegaly. A fatal coagulopathy supervened. The clinical picture and the bone marrow findings indicated a haemophagocytic syndrome and a lymph node biopsy disclosed an EBV-positive Hodgkin's lymphoma. EBV serology pointed at viral reactivation and a high EBV DNA content was detected in serum by real-time quantitative PCR analysis (5.5 x 10(6) copies per mL). The case history is presented and the literature is reviewed. |
| Databáze: | OpenAIRE |
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