Data on sodium tetraborate as a modulation of hypertrophic intracellular signals
| Autor: | G. Díaz-Rosas, Salomón Hernández-Gutiérrez, J. Roque-Jorge, Adolfo López-Torres, Alejandra Contreras-Ramos, A.J. García-Chequer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Science (General)
Computer applications to medicine. Medical informatics R858-859.7 Heart failure Muscle hypertrophy 03 medical and health sciences Q1-390 0302 clinical medicine MEF2C Transcription factor Myogenin Glyceraldehyde 3-phosphate dehydrogenase 030304 developmental biology Data Article 0303 health sciences Multidisciplinary biology Chemistry Isoproterenol NFAT Sodium tetraborate Housekeeping gene Cell biology Cardiac hypertrophy biology.protein Cardiomyocite 030217 neurology & neurosurgery Intracellular |
| Zdroj: | Data in Brief, Vol 35, Iss, Pp 106889-(2021) Data in Brief Europe PubMed Central |
| ISSN: | 2352-3409 |
| Popis: | The present work benefits the use of sodium tetraborate to prevent and treat hypertrophic cardiac. The data obtained from the work could serve as a reference point to compare with data obtained in vivo studies with cardiac damage. This research will be an advantage for future researches to stimulate the ones focused on developing food supplements to prevent heart diseases such as cardiac hypertrophic. This article also indicates the data on the optimal concentration of isoproterenol as an inducer of hypertrophy in cardiomyocytes. Also, data of the cytotoxic effect of sodium tetraborate on normal cardiomyocytes is revealed. Finally, data of viability, cell size, proliferation nuclear antigen (PCNA) and apoptosis is shown. The expression of transcription factors linked to hypertrophy such as GATA-4, MEF2c, NFAT, CDk9, and myogenin was also quantified by immunofluorescence. The mRNA expression of adrenergic receptors (alpha and beta), AKT1 and Erk1 / 2 and genes of early response to hypertrophy (c-myc, c-fos, c-jun) are also shown as Cts of RT-qPCR. GAPDH and 18 s were used as housekeeping genes. |
| Databáze: | OpenAIRE |
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