The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis
| Autor: | Safiye Dondurmaci, Seval Aydin, Resat Ozaras, Şansın Tüzün, Nihal Ozaras, Hafize Uzun, Fikret Tüzün |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty medicine.medical_treatment Flurbiprofen Osteoarthritis Placebo Gastroenterology Internal medicine Arthropathy medicine Humans Orthopedics and Sports Medicine Prospective Studies Aged Pain Measurement Chemotherapy biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal Middle Aged Osteoarthritis Knee musculoskeletal system medicine.disease Surgery Serum cytokine Enzyme inhibitor biology.protein Cytokines Female Propionates business Tiaprofenic acid medicine.drug Interleukin-1 |
| Zdroj: | Acta orthopaedica Scandinavica. 72(5) |
| ISSN: | 0001-6470 |
| Popis: | 39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-alpha levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis. |
| Databáze: | OpenAIRE |
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