Recurrent implantation failure is associated with increased levels of fetuin-A/alpha2-Heremans-Schmid-glycoprotein
| Autor: | Namik Delibas, A. Seval Ozgu-Erdinc, Z. Asli Oskovi-Kaplan, Salim Erkaya, Emel Kiyak Caglayan, Ayşe Yeşim Göçmen, Nafiye Yilmaz, Saynur Yilmaz, Yaprak Engin-Ustun |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
alpha-2-HS-Glycoprotein medicine.medical_treatment Fertilization in Vitro Intracytoplasmic sperm injection Proinflammatory cytokine Andrology 03 medical and health sciences 0302 clinical medicine medicine Humans Embryo Implantation 030212 general & internal medicine 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Insulin Obstetrics and Gynecology Trophoblast Fetuin Embryo transfer medicine.anatomical_structure ROC Curve Reproductive Medicine Case-Control Studies Female business Infertility Female alpha-2-HS-glycoprotein |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 248:1-4 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2020.03.005 |
| Popis: | Recurrent implantation failure is defined as the absence of implantation, after two or three consecutive cycles of in-vitro fertilization (IVF), intracytoplasmic sperm injection or frozen embryo replacement. Human fetuin-A/alpha2-Heremans-Schmid-glycoprotein is a plasma protein secreted by the liver that modulates insulin action in adipocytes. Increased fetuin-A promotes adipocyte dysfunction which results in decreased adiponectin and increased fatty acids and inflammatory cytokines. Fatty acids and inflammatory cytokines were previously reported in implantation failure. Also, fetuin-A inhibits receptor tyrosine kinase activity in trophoblast growth factors which decrease trophoblast viability and invasion. In this study, we aimed to find the association between fetuin-A and implantation failure.A total of 78 women were included in this case-control study. Serum fetuin-A concentrations were measured in 42 women with recurrent IVF failure and 36 healthy women with regular cycles.The mean serum fetuin-A levels of implantation failure and control women were 257.77 ± 32.18 and 219.59 ± 48.86 respectively with a p-value0.001 (independent samples t-test). Our results showed a statistically significant difference between serum fetuin-A levels of implantation failure women and controls.So far reasons for implantation failure are only partially understood. The current study reveals the association between implantation failure and fetuin-A. Further studies with large population sizes are needed to investigate whether fetuin-A can be used as a marker before controlled ovarian stimulation began or regulation of fetuin-A levels with treatment or lifestyle interventions can improve implantation success. |
| Databáze: | OpenAIRE |
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