Comparison of Popliteal Lymph Node Responses in Various Strains of Rats
| Autor: | Jean-Philippe Brouland, Thierry Vial, Caroline Patriarca, F. Verdier, Jacques Descotes |
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| Rok vydání: | 1994 |
| Předmět: |
Male
0301 basic medicine Phenytoin endocrine system medicine.medical_specialty Health Toxicology and Mutagenesis Procainamide Barbital Toxicology Streptozocin Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Species Specificity Immunity Internal medicine Isoniazid medicine Animals Rats Wistar Lymph node Autoimmune disease 030102 biochemistry & molecular biology business.industry Rats Inbred Strains General Medicine medicine.disease Streptozotocin Hindlimb Rats medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Female Lymph Nodes business medicine.drug |
| Zdroj: | Human & Experimental Toxicology. 13:455-460 |
| ISSN: | 1477-0903 0960-3271 |
| Popis: | Outbred (namely Wistar and Sprague-Dawley) and inbred (Wistar-Furth, Lewis, Fisher 344 and Brown-Norway) strains of rats were screened for their responses to reference compounds in the popliteal lymph node (PLN) assay. Streptozotocin and diphenylhydantoin gave positive responses as evidenced by increased weight and cellularity indices in all strains used whereas procainamide, isoniazid and barbital consistently gave negative responses. Although these findings overall are in agreement with previous investigations involving these compounds, the lack of marked interstrain differences in PLN responses argues against a strong immunogenetically controlled mechanism as could be assumed in presumably auto-immune reactions. The question is raised whether drug-induced side-effects predicted by the PLN assay are basically non-autoimmune as suggested by clinical and immunological findings in man. |
| Databáze: | OpenAIRE |
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