Unexpected and striking effect of heparin-free dialysis on cytokine release
| Autor: | Michal Mysliwiec, Beata Naumnik, Alicja Rydzewska-Rosołowska, Jacek Borawski, Joanna Gozdzikiewicz-Lapinska, Ewa Koc-Zorawska |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Adolescent medicine.drug_class Urology medicine.medical_treatment 030232 urology & nephrology Pharmacology Proinflammatory cytokine Young Adult 03 medical and health sciences 0302 clinical medicine Endostatin Renal Dialysis Internal medicine medicine Humans 030212 general & internal medicine Enoxaparin Renal Insufficiency Chronic Chemokine CCL2 Dialysis Aged Aged 80 and over Heparin business.industry Anticoagulant Anticoagulants Membranes Artificial Nephrology – Original Paper Middle Aged Activin A Activins Endostatins Monocyte chemoattractant protein-1 Cytokine Hemodialysis Immunology Female Heparin-grafted membrane business medicine.drug |
| Zdroj: | International Urology and Nephrology |
| ISSN: | 1573-2584 0301-1623 |
| DOI: | 10.1007/s11255-017-1589-8 |
| Popis: | Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane—Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Nineteen stable HD patients were dialyzed with or without heparin, and plasma levels of MCP-1, ES and Act-A were measured after such a dialysis. During HD with Evodial, the intradialytic levels of all three cytokines were 2–3 folds lower. The between-anticoagulant differences were significant over time for all three cytokines: MCP-1 (P |
| Databáze: | OpenAIRE |
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