Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease
| Autor: | Kevin Taddei, Hugo Vanderstichele, Ralph N. Martins, Preeti Dave, Mitra Elmi, Kaj Blennow, Pratishtha Chatterjee, Cintia B. Dias, Steve Pedrini, Tejal M. Shah, Hamid R. Sohrabi, Kathryn Goozee, Prita R. Asih, Kaikai Shen, Henrik Zetterberg |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Risk medicine.medical_specialty Amyloid β Standardized uptake value Disease Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Apolipoproteins E Cognition Alzheimer Disease Internal medicine medicine Humans Blood markers Aged Aged 80 and over Amyloid beta-Peptides business.industry Surrogate endpoint General Neuroscience General Medicine Pet imaging Peptide Fragments Psychiatry and Mental health Clinical Psychology 030104 developmental biology Endocrinology Potential biomarkers Positron-Emission Tomography Biomarker (medicine) Female Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of Alzheimer's disease : JAD. 71(3) |
| ISSN: | 1875-8908 |
| Popis: | Background: Aberrant amyloid-β (Aβ) deposition in the brain occurs two decades prior to the manifestation of Alzheimer’s disease (AD) clinical symptoms and therefore brain Aβ load measured using PET serves as a gold standard biomarker for the early diagnosis of AD. However, the uneconomical nature of PET makes blood markers, that reflect brain Aβ deposition, attractive candidates for investigation as surrogate markers. Objective:Investigation of plasma Aβ as a surrogate marker for brain Aβ deposition in cognitively normal elderly individuals. Methods: Plasma Aβ40 and Aβ42 concentrations were measured using the ultrasensitive Single Molecule Array (Simoa) assay in 95 cognitively normal elderly individuals, who have all undergone PET to assess brain Aβ deposition. Based on the standard uptake value ratios (SUVR) obtained from PET imaging, using the tracer 18F-Florbetaben, plasma Aβ was compared between 32 participants assessed to have low brain Aβ load (Aβ–, SUVR |
| Databáze: | OpenAIRE |
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