Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma
| Autor: | Peri K Rosenstein, Melissa D. Sánchez, Amy C. Durham, Kevin M O'Brien, Daphne C Clendaniel, Braelyn J Bankoff |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Colorado Lung Neoplasms 040301 veterinary sciences Gallbladder Neuroendocrine Carcinoma 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Dogs Biomarkers Tumor Medicine Animals Neuroendocrine carcinoma Dog Diseases Full Scientific Reports Neoplasm Metastasis Retrospective Studies Philadelphia General Veterinary business.industry Gallbladder Liver Neoplasms 04 agricultural and veterinary sciences Carcinoma Neuroendocrine medicine.anatomical_structure 030220 oncology & carcinogenesis Immunohistochemistry Female Gallbladder Neoplasms business |
| Zdroj: | J Vet Diagn Invest |
| ISSN: | 1943-4936 |
| Popis: | In this retrospective descriptive study, we characterized the clinical, histologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma (GB-NEC). Immunohistochemical stains for neuroendocrine (neuron-specific enolase [NSE], chromogranin A, synaptophysin) and gastrin markers were evaluated, and clinicopathologic and follow-up data were obtained for all cases. The average age at diagnosis was 8.9 y, and breeds included 6 Boston Terriers, 2 Bichon Frise, 1 Poodle, 1 English Bulldog, 1 French Bulldog, and 2 mixed-breed dogs. Boston Terriers were overrepresented in this cohort, and therefore a breed predilection is possible. Most dogs were presented with emesis and elevated liver enzyme activities: 13 of 13 had elevated alanine aminotransferase and alkaline phosphatase activities; 8 of 13 had elevated aspartate aminotransferase activity; 7 of 13 had elevated gamma-glutamyl transferase activity. Abdominal ultrasound and/or exploratory surgery revealed a gallbladder mass. All neoplasms had similar histologic features and positive immunoreactivity for NSE, chromogranin A, synaptophysin, and gastrin. Vascular invasion was noted in 8 of 13 neoplasms, and metastasis was present in 6 of 13 cases (4 hepatic and 2 pulmonary metastases). The median survival time was 3.7 y in patients who died; 5 of 8 deaths were directly attributed to the GB-NEC, 3 of which had metastatic spread. GB-NECs have the potential to metastasize; however, surgical excision may be curative in a subset of dogs. |
| Databáze: | OpenAIRE |
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