Activated Src Protein Tyrosine Kinase Is Overexpressed in Late-Stage Human Ovarian Cancers
| Autor: | Gary E. Gallick, T. Christopher Windham, Michael T. Deavers, Peter F. Thall, Robert C. Bast, Veronica C. Estrella, Jon R. Wiener, Gordon B. Mills, Nila U. Parikh |
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| Rok vydání: | 2003 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty endocrine system diseases Receptor ErbB-2 Ovary Biology Tumor Cells Cultured medicine Humans Neoplasm Staging Ovarian Neoplasms Proto-Oncogene Proteins c-yes Kinase Obstetrics and Gynecology medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Epithelium Enzyme Activation src-Family Kinases medicine.anatomical_structure Oncology Cancer research Female Ovarian cancer HT29 Cells Tyrosine kinase Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Gynecologic Oncology. 88:73-79 |
| ISSN: | 0090-8258 |
| Popis: | Objective. The objective of this study was to determine if the Src tyrosine kinase is overexpressed and activated in late-stage human ovarian cancers. Methods. Western analysis and immune complex kinase assays were performed on a panel of human ovarian cancer cell lines and normal ovarian epithelial cell cultures, and immunohistochemical analysis for Src and activated Src were performed on a panel of late-stage human ovarian tumors. Results and conclusions. Src is overexpressed and activated in a majority of late-stage ovarian tumors as well as in a panel of cultured malignant human ovarian epithelium grown in vitro, but not in normal ovarian epithelium (NOE) or immortalized NOE. Src overexpression was found to be frequently, but not always, associated with HER-2/ neu overexpression, but no statistical association between Src and Her-2/ neu overexpression could be demonstrated. |
| Databáze: | OpenAIRE |
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