Hypoxia reveals a new function of Foxn1 in the keratinocyte antioxidant defense system

Autor: Sylwia Machcinska, Katarzyna Walendzik, Marta Kopcewicz, Joanna Wisniewska, Anne Rokka, Mirva Pääkkönen, Mariola Slowinska, Barbara Gawronska‐Kozak
Rok vydání: 2022
Předmět:
Zdroj: The FASEB Journal. 36
ISSN: 1530-6860
0892-6638
DOI: 10.1096/fj.202200249rr
Popis: Skin exposed to environmental threats, including injuries and oxidative stress, develops an efficient but not fully recognized system of repair and antioxidant protection. Here, using mass spectrometry analysis (LC-MS/MS), followed by in vitro and in vivo experiments, we provided evidence that Foxn1 in keratinocytes regulates elements of the electron transport chain and participates in the thioredoxin system (Txn2, Txnrd3, and Srxn1) induction, particularly in a hypoxic environment. We first showed that Foxn1 in keratinocytes upregulates glutathione thioredoxin reductase 3 (Txnrd3) protein expression, and high levels of Txnrd3 mRNA were detected in injured skin of Foxn1
Databáze: OpenAIRE
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