The Regulatory/Cytotoxic Graft-Infiltrating T Cells Differentiate Renal Allograft Borderline Change From Acute Rejection
| Autor: | Philippe Lang, Hicham Mansour, Catherine Dehoulle-Poillet, Jean Pierre Farcet, François Berrehar, Sabine Le Gouvello, Philippe Grimbert, Karine Dahan, Vincent Audard, Françoise Roudot-Thoraval, Dominique Desvaux |
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| Rok vydání: | 2007 |
| Předmět: |
Graft Rejection
Pathology medicine.medical_specialty T cell T-Lymphocytes Regulatory Granzymes Immune system medicine Humans Cytotoxic T cell RNA Messenger skin and connective tissue diseases Transplantation Kidney biology business.industry FOXP3 Forkhead Transcription Factors Kidney Transplantation Cellular Infiltrate Interleukin-10 Granzyme B medicine.anatomical_structure Granzyme Immunology biology.protein Transplantation Tolerance sense organs business Biomarkers T-Lymphocytes Cytotoxic |
| Zdroj: | Transplantation. 83:341-346 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/01.tp.0000248884.71946.19 |
| Popis: | The interpretation of cellular infiltrate from renal transplant recipients with borderline (BL) changes is still a challenging problem. To analyze the immune phenotype of such infiltrate, we quantified the mRNA expression of Foxp3 and interleukinL-10 and granzyme B (GB) in 15 kidney biopsies with BL changes. Controls were patients presenting type IA acute rejection and nonrejecting patients. Only levels of GB mRNA correlated significantly with response to antirejection therapy. Levels of Foxp3 mRNA in BL changes were intermediate between type IA acute rejection and nonrejecting controls. To determine the balance of alloagressive to graft-protecting T cells, we quantified the Foxp3/GB ratio. BL changes T cells infiltrate expressed a significantly higher Foxp3/GB ratio than that in IA acute rejection. These results suggest that T cell infiltrate from BL change exhibit a tolerogenic rather than a cytotoxic phenotype. |
| Databáze: | OpenAIRE |
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