Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola)
| Autor: | Carlos G. das Neves, Olga Nicolas de Francisco, Neil E. Anderson, Alberto Marco, Carlos Sacristán, Carles Juan-Sallés, Fernando Esperón, Ana Carolina Ewbank, Elena Neves |
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| Přispěvatelé: | University of Edinburgh, Norwegian University of Life Sciences, Generalitat de Catalunya, Fundação de Amparo à Pesquisa do Estado de São Paulo, Nicolas de Francisco, Olga, Esperón, Fernando, Juan-Sallés, Carles, Ewbank, Ana Carolina, das Neves, Carlos G., Neves, Elena, Anderson, Neil, Sacristán, Carlos |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Lung adenocarcinoma
Mustelid Preputial cystadenoma preputial cystadenoma Pathology medicine.medical_specialty Lymphoma 040301 veterinary sciences viruses Population Biliary cystadenoma lymphoma mustelid 0403 veterinary science Pathogenesis Gross examination 03 medical and health sciences Gammaherpesvirinae biliary cystadenoma herpesvirus Neoplasms biology.animal medicine Animals Mink education 030304 developmental biology 0303 health sciences education.field_of_study General Veterinary General Immunology and Microbiology biology Endangered Species Mustela lutreola Herpesvirus Herpesviridae Infections 04 agricultural and veterinary sciences General Medicine lung adenocarcinoma medicine.disease biology.organism_classification Immunohistochemistry Animals Zoo Histopathology |
| Zdroj: | Nicolas de Francisco, O, Esperón, F, Juan-Sallés, C, Ewbank, A C, das Neves, C G, Marco, A, Neves, E, Anderson, N & Sacristán, C 2020, ' Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) ', Transboundary and Emerging Diseases . https://doi.org/10.1111/tbed.13713 |
| Popis: | 13 Päg. Centro de Investigación en Sanidad Animal (CISA) The European mink (Mustela lutreola) is a riparian mustelid, considered one of the most endangered carnivores in the world. Alpha, beta and gammaherpesviruses described in mustelids have been occasionally associated with different pathological processes. However, there is no information about the herpesviruses species infecting European minks. In this study, 141 samples of swabs (oral, conjunctival, anal), faeces and tissues from 23 animals were analysed for herpesvirus (HV) using a pan-HV-PCR assay. Two different, potentially novel, gammaherpesvirus species were identified in 12 samples from four animals (17.3%), and tentatively named Mustelid gammaherpesvirus-2 (MUGHV-2) and MuGHV-3. Gross examination was performed on dead minks (n = 11), while histopathology was performed using available samples from HV-positive individuals (n = 2), identifying several neoplasms, including B-cell lymphoma (identified by immunohistochemistry) with intralesional syncytia and intranuclear inclusion bodies characteristic of HV (n = 1), pulmonary adenocarcinoma (n = 1), and biliary (n = 1) and preputial (n = 1) cystadenomas, as well as other lesions (e.g., axonal vacuolar degeneration [n = 2] and neuritis [n = 1]). Viral particles, consistent with HVs, were observed by electron microscopy in the mink with neural lymphoma and inclusion bodies. This is the first description of neoplasms and concurrent gammaherpesvirus infection in European minks. The pathological, ultrastructural and PCR findings (MuGHV-2) in the European mink with lymphoma strongly suggest a potential role for this novel gammaherpesvirus in its pathogenesis, as it has been reported in other HV-infected species with lymphoma. The occurrence of neural lymphoma with intralesional syncytia and herpesviral inclusions is, however, unique among mammals. Further research is warranted to elucidate the potential oncogenic properties of gammaherpesviruses in European mink and their epidemiology in the wild population. Innovation Initiative Grant (IIG) of the Edinburgh Fund (University of Edinburgh); Norwegian University of Life Sciences; Generalitat de Catalunya; São Paulo Research Foundation, Grant/Award Number: 2018/20956-08 and 2018/25069-7; University of Edinburgh |
| Databáze: | OpenAIRE |
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