Gene XRCC1Arg399Gln polymorphism and its genotype variations: clinical associations in Egyptian systemic lupus erythematosus patients
| Autor: | Haidy E. Zidan, Mirvat Abd El-Hameed El-Toukhy, Mohamed Mortada, Noha A. Abdelsalam |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
DNA repair Population SLE Diseases of the musculoskeletal system 03 medical and health sciences chemistry.chemical_compound XRCC1 0302 clinical medicine Genotype Medicine Polymorphism education Gene Allele frequency Alleles 030203 arthritis & rheumatology education.field_of_study Creatinine XRCC1Arg399Gln business.industry 030104 developmental biology chemistry RC925-935 Immunology Gene polymorphism business |
| Zdroj: | Egyptian Rheumatology and Rehabilitation, Vol 47, Iss 1, Pp 1-8 (2020) |
| ISSN: | 2090-3235 |
| Popis: | Background Impaired deoxyribonucleic acid (DNA) repair may induce an autoimmune response in susceptible individuals. The association between DNA repair gene XRCC1 Arg399Gln gene polymorphism and susceptibility of systemic lupus erythematosus (SLE) is controversial. This study aimed to detect the association of XRCC1 Arg399Gln gene polymorphism with SLE and its clinical manifestations in the Egyptian population. Results A significant association was found between weight loss and genotype GG (P = 0.048); however, genotype AG was significantly associated with high serum creatinine and low C3 level (P = 0.039, P = 0.009, respectively). On the other hand, there was no significant difference between patients and controls regarding genotype and allele frequency. Conclusions An association was found between weight loss, high serum creatinine, and low C3 level and genotypes of XRCC1 Arg 399 Gln gene polymorphism. |
| Databáze: | OpenAIRE |
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