Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors
| Autor: | Bénédicte Lemmers, Jean Marie Blanchard, Nawal Bendris |
|---|---|
| Přispěvatelé: | Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Cytoplasm Epithelial-Mesenchymal Transition DNA Repair Transcription Genetic DNA repair Mitosis [SDV.CAN]Life Sciences [q-bio]/Cancer Review [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Mice Cyclin-dependent kinase Cyclins Neoplasms Cyclin E medicine Animals Humans Cyclin D1 Neoplasm Invasiveness [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Cytoskeleton Interphase Molecular Biology ComputingMilieux_MISCELLANEOUS Cyclin Cell Nucleus Kinase [SDV.BA]Life Sciences [q-bio]/Animal biology Cell Cycle Cell Biology Cell cycle Cyclin-Dependent Kinases Cell biology Cell nucleus Phenotype medicine.anatomical_structure biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Female DNA Damage Developmental Biology |
| Zdroj: | Cell Cycle Cell Cycle, Taylor & Francis, 2015, ⟨10.1080/15384101.2014.998085⟩ Cell Cycle, Taylor & Francis, 2015, 14 (12), pp.1786-1798. ⟨10.1080/15384101.2014.998085⟩ |
| ISSN: | 1538-4101 1551-4005 |
| DOI: | 10.1080/15384101.2014.998085⟩ |
| Popis: | While targeting experiments carried out on the genes encoding many cell cycle regulators have challenged our views of cell cycle control, they also suggest that redundancy might not be the only explanation for the observed perplexing phenotypes. Indeed, several observations hint at functions of cyclins and CDK inhibitors that cannot be accounted for by their sole role as kinase regulators. They are found involved in many cellular transactions, depending or not on CDKs that are not directly linked to cell cycle control, but participating to general mechanisms such as transcription, DNA repair or cytoskeleton dynamics. In this review we discuss the roles that these alternative functions might have in cancer cell proliferation and migration that sometime even challenge their definition as proliferation markers. |
| Databáze: | OpenAIRE |
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