Aqueous extract of chives (Allium schoenoprasum L.) plant impairs erythrocyte deformability in sickle cell patients
| Autor: | Okan Arihan, Romain Fort, Gökhan Oto, Yılmaz Koçak, Elie Nader, Philippe Connes |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Erythrocytes
Physiology Chive Cell Erythrocytes Abnormal Anemia Sickle Cell Pharmacology 030226 pharmacology & pharmacy Mice 03 medical and health sciences 0302 clinical medicine food Erythrocyte Deformability Physiology (medical) medicine Animals Humans Erythrocyte deformability Incubation biology Chemistry Hematology Heparin medicine.disease Allium schoenoprasum biology.organism_classification Sickle cell anemia food.food Hemolysis medicine.anatomical_structure 030220 oncology & carcinogenesis Allium Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Clinical Hemorheology and Microcirculation. 79:357-361 |
| ISSN: | 1875-8622 1386-0291 |
| DOI: | 10.3233/ch-201036 |
| Popis: | Sickle cell anemia (SCA) is a genetic disorder characterized by chronic hemolysis and the presence of erythrocytes with low deformability, which may trigger vaso-occlusive crises. We tested the in-vitro effects of aqueous extract of chives (Allium schoenoprasum L.) on erythrocyte deformability of SCA patients. Blood samples from 6 apparently healthy volunteers and 5 SCA patients were collected into heparin coated tubes. Both apparently healthy and SCA patient blood samples were incubated with 80μg/mL chives plant aqueous extract at 37°C for 60 min and erythrocyte deformability was measured by ektacytometry (3 Pa and 30 Pa; 37°C). Results of incubation of apparently healthy blood samples with plant extract showed that incubation did not alter erythrocyte deformability significantly. However, for SCA blood samples, erythrocyte deformability decreased significantly with plant extract exposure at 3 Pa (p |
| Databáze: | OpenAIRE |
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