The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study

Autor: Ilma Rita Korponay-Szabó, David Hervás, Paula Crespo-Escobar, Sibylle Koletzko, Riccardo Troncone, Carmen Ribes-Koninckx, Renata Auricchio, Sabine L. Vriezinga, Els Stoopman, Eva Martínez-Ojinaga, Sanja Kolaček, Raanan Shamir, Judit Gyimesi, Isabel Polanco, Gemma Castillejo, M.L. Mearin, Hania Szajewska, Katharina J. Werkstetter
Přispěvatelé: Unitat de Recerca en Pediatria, Nutrició i Desenvolupament Humà, Medicina i Cirurgia, Universitat Rovira i Virgili, Crespo Escobar, Paula, Mearin, Maria Luisa, Hervás, David, Auricchio, Renata, Castillejo, Gemma, Gyimesi, Judit, Martinez Ojinaga, Eva, Werkstetter, Katharina, Vriezinga, Sabine Lisa, Korponay Szabo, Ilma Rita, Polanco, Isabel, Troncone, Riccardo, Stoopman, El, Kolaček, Sanja, Shamir, Raanan, Szajewska, Hania, Koletzko, Sibylle, Ribes Koninckx, Carmen
Předmět:
0301 basic medicine
Male
Medicine (miscellaneous)
Disease
0002-9165
Gastroenterology
0302 clinical medicine
Risk groups
Risk Factors
Prospective Studies
Genetic risk
Ciències de la salut
chemistry.chemical_classification
Nutrition and Dietetics
Ciencias de la salud
Diet Records
HLA
Europe
Child
Preschool
Malaltia celíaca
030211 gastroenterology & hepatology
Female
Child Nutritional Physiological Phenomena
Infants
Cohort study
medicine.medical_specialty
Glutens
Human leukocyte antigen
Placebo
03 medical and health sciences
European cohort
children
Internal medicine
HLA-DQ Antigens
medicine
Humans
Genetic Predisposition to Disease
Autoantibodies
Consumption (economics)
business.industry
Health sciences
nutritional and metabolic diseases
Infant
Feeding Behavior
Gluten
digestive system diseases
Diet
Celiac Disease
030104 developmental biology
chemistry
Haplotypes
gluten
business
celiac disease
Zdroj: Europe PubMed Central
American Journal of Clinical Nutrition, 105(4), 890-896
American Journal of Clinical Nutrition
AMERICAN JOURNAL OF CLINICAL NUTRITION
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ISSN: 0002-9165
DOI: 10.3945/ajcn.116.144352
Popis: Background: We previously found that the introduction of small quantities of gluten at 4-6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consumption of high amounts of gluten early in life has been suggested to increase CD risk.Objective: The aim of this study was to evaluate this hypothesis by using data from the previous study of the PreventCD trial (www.preventcd.com).Design: Gluten intake was prospectively quantified by using specific food records between 11 and 36 mo of age in 715 children positive for the human leukocyte antigen (HLA)-DQ2 and/or HLA-DQ8 from 5 European countries. According to the PreventCD protocol, infants received 100 mg immunologically active gluten/d or placebo from 4 to 6 mo of age, with a stepwise and fixed gluten increase until age 10 mo and unrestricted intake thereafter. The primary outcome of the present study was the impact of the amount of gluten consumed from age 10 mo onward on CD development.Results: Mean daily gluten intakes from 10 mo onward were significantly different between countries for children at all ages (P < 0.001) but not between children who developed CD and those who did not within the same country (P > 0.05). The variables country, sex, intervention group, and gluten consumption pattern did not show significant associations with CD development risk (HRs not significant). In addition, the interaction between HLA risk group and gluten consumption pattern showed no significant risk on CD development, except for the DQ2.2/DQ7 haplotype (HR: 5.81; 95% CI: 1.18, 28.74; P = 0.031).Conclusions: Gluten consumption patterns as well as the amount of gluten consumed at 11-36 mo of age do not influence CD development for most related HLA genotypes in children with a genetic risk. This study reports the gluten consumption pattern in children at risk of CD from different European countries. This trial was registered at www.controlled-trials.com as ISRCTN74582487.
Databáze: OpenAIRE
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