The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery
| Autor: | Stefania Lucia Nori, Rosaria Meccariello, Antonietta Santoro, Marianna Marino, Elena Mele, Andrea Viggiano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell signaling
medicine.drug_class cancer central nervous system endocannabinoid system estrogens reproduction Central nervous system Estrogen receptor Review Biology Catalysis Inorganic Chemistry lcsh:Chemistry Neoplasms medicine Animals Humans Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Neuronal Plasticity Organic Chemistry General Medicine Endocannabinoid system Computer Science Applications Crosstalk (biology) medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Estrogen Synaptic plasticity Female Neuroscience Hormone Endocannabinoids Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 972, p 972 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity, neuroendocrine functions, reproduction, and immune response among others all require the activity of functional ECS, with the onset of disease in case of ECS impairment. Estrogens, classically considered as female steroid hormones, regulate growth, differentiation, and many other functions in a broad range of target tissues and both sexes through the activation of nuclear and membrane estrogen receptors (ERs), which leads to genomic and non-genomic cell responses. Since ECS function overlaps or integrates with many other cell signaling systems, this review aims at updating the knowledge about the possible crosstalk between ECS and estrogen system (ES) at both central and peripheral level, with focuses on the central nervous system, reproduction, and cancer. |
| Databáze: | OpenAIRE |
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