Hairy Cell Leukemia: Diagnostic Pathology
| Autor: | Robert W. Sharpe, Kelly Bethel |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Pathology Lymphoma B-Cell Disease Diagnosis Differential Antigens Neoplasm Bone Marrow Internal medicine Biomarkers Tumor medicine Humans Hairy cell leukemia Leukemia Hairy Cell Hematology business.industry Lymphoma Non-Hodgkin Anatomical pathology Flow Cytometry medicine.disease B-cell neoplasm Oncology Lymph Nodes Differential diagnosis business Hematopathology Tumor immunology Spleen |
| Zdroj: | Hematology/Oncology Clinics of North America. 20:1023-1049 |
| ISSN: | 0889-8588 |
| DOI: | 10.1016/j.hoc.2006.06.010 |
| Popis: | The pathology of HCL has been reviewed with a focus on the diagnostic hematopathology of this rare, but fascinating, disease. The discrimination of HCL from other B-cell lymphoproliferations, particularly HCL-V and SMZL, has been emphasized. The unique responsiveness of HCL to 2-CdA and other chemotherapeutic agents makes this distinction critical. Fortunately, HCL has consistent cytologic, histologic, cytochemical, and immunologic features that make classification reliable and reproducible. Less straightforward is the differential diagnosis of SMZL and HCL-V, problematic because of the rarity of both disorders, lack of discriminating evidence-based criteria, and perhaps a biologic kinship between these two disorders that share many clinical and pathologic features. Fortunately, this is not a clinically critical distinction. |
| Databáze: | OpenAIRE |
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