Factors influencing dabigatran or warfarin medication persistence in patients with nonvalvular atrial fibrillation
| Autor: | Yong Li, Chad Moretz, Cheng Wang, Prachi Arora, Stephen Sander, Pranav K. Gandhi, Srinivas Annavarapu, George Andrews |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual 030204 cardiovascular system & hematology Medicare Antithrombins Drug Costs Dabigatran Persistence (computer science) Medication Adherence Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Atrial Fibrillation Medicine Humans In patient 030212 general & internal medicine Claims database Aged Proportional Hazards Models Retrospective Studies business.industry Health Policy Hazard ratio Warfarin Anticoagulants Atrial fibrillation medicine.disease United States Stroke Medication Persistence Costs and Cost Analysis Female business medicine.drug |
| Zdroj: | Journal of comparative effectiveness research. 7(7) |
| ISSN: | 2042-6313 |
| Popis: | Factors influencing differences in persistence between dabigatran and warfarin in patients with nonvalvular atrial fibrillation (NVAF) remain unclear. Aim: Compare differences in persistence between new dabigatran and warfarin users in patients newly diagnosed with NVAF, adjusting for sociodemographics, clinical characteristics, patient out-of-pocket cost and other covariates. Methods: A retrospective matched-cohort study was conducted using a US claims database of Medicare and commercially insured patients with NVAF aged≥ 18 years. Persistence and monthly out-of-pocket costs for dabigatran or warfarin were calculated and adjusted for covariates using Cox proportional hazard models. Results & conclusion: Unadjusted persistence was significantly lower among dabigatran users (n = 1025) compared with matched warfarin users (38 vs 46%). Adjusting for covariates rendered this difference insignificant (hazard ratio = 0.930). |
| Databáze: | OpenAIRE |
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