The Emerging Role of Sperm-Associated Antigen 6 Gene in the Microtubule Function of Cells and Cancer
| Autor: | Dafang Zheng, Li Ma, Z. Peter Wang, Qi Wang, Damin Chai, Jing-Ping Wang, Shiwu Wu, Yisheng Tao, Zheng-Qi Bao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research proliferation Biology lcsh:RC254-282 Article Metastasis SPAG6 03 medical and health sciences Transduction (genetics) 0302 clinical medicine Antigen medicine cancer Pharmacology (medical) Gene Neurogenesis apoptosis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell biology 030104 developmental biology Oncology Apoptosis 030220 oncology & carcinogenesis Cancer cell Molecular Medicine Biogenesis microtubule |
| Zdroj: | Molecular Therapy: Oncolytics, Vol 15, Iss, Pp 101-107 (2019) Molecular Therapy Oncolytics |
| ISSN: | 2372-7705 |
| Popis: | Accumulated evidence shows that sperm-associated antigen 6 (SPAG6) gene has multiple biological functions. It maintains the normal function of a variety of cells including ciliary/flagellar biogenesis and polarization, neurogenesis, and neuronal migration. Moreover, SPAG6 is found to be critically involved in auditory transduction and the fibroblast life cycle. Furthermore, SPAG6 plays an essential role in immuno-regulation. Notably, SPAG6 has been demonstrated to participate in the occurrence and progression of a variety of human cancers. New evidence shows that SPAG6 gene regulates tumor cell proliferation, apoptosis, invasion, and metastasis. Therefore, in this review, we describe the physiological function and mechanism of SPAG6 in human normal cells and cancer cells. We also highlight that SPAG6 gene may be an effective biomarker for the diagnosis of human cancer. Taken together, targeting SPAG6 could be a novel strategy for the treatment of human diseases including cancer. Keywords: SPAG6, microtubule, apoptosis, cancer, proliferation |
| Databáze: | OpenAIRE |
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